| 전기자극을 이용한 토끼 외안근 수축 |
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박운철, 서종모, 김성준, 유형곤, 유영석, 정흠 |
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1Department of Ophthalmology, Seoul National University College of Medicine,2Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul,3Department of Ophthalmology, Dongguk University College of Medicine, Goyang, Korea |
| Electrical Stimulation for Extraocular Muscle Contraction in Rabbit |
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Un Chul Park, Jong-Mo Seo, Seong Joon Kim, Hyeong Gon Yu, Young Suk Yu, Hum Chung |
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| Abstract |
Purpose
To verify the contraction of extraocular muscle by electrical stimulation and to investigate the appropriate stimulation parameters for muscle contraction. Methods: Under the general anesthesia, anterior part of superior rectus was maximally exposed after removal of upper lid in the rabbit eye. Using four different electrodes made of various materials and shapes, electrical stimuli with various stimulation parameters were delivered and the responses of the superior rectus muscle were observed. Under the electrical stimulation with the platinum rod electrode, longitudinal contraction length according to the stimulation voltage level and the distance between electrodes was analyzed. Results: Under the electrical stimulation with the platinum rod electrode, longitudinal contraction over full width of superior rectus muscle was observed without muscle injury or oxidative reaction on the surface of the electrode, and the muscle contraction was maintained during the stimulation independent of pulse duration, frequency or interval. Definite longitudinal contraction was observed over 2.0 V of voltage stimulus, but the length of maximal contraction was about 1.0 mm, which was not enough to rotate the eyeball. The length of longitudinal contraction was proportionally increased according to the stimulation voltage level, but showed inverse correlation with the distance between the electrodes. Conclusions: The electrically-evoked extraocular muscle contraction in rabbit was verified, and the length of the longitudinal contraction could be controlled by the stimulation parameters. However, further investigation is needed to provoke efficient extraocular muscle contraction for the rotation of the eyeball. (Korean J Optom Vis Sci 2007;6(1):7-11) |
| Key Words:
Electrical muscle stimulation, Extraocular muscle paralysis, Neural prosthesis, Paralytic strabismus |
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